CJC-1295 (with Drug Affinity Complex)
Long-Acting GHRH Analog • 30 Amino Acids
CAS: 863288-34-0
CJC-1295 with DAC is a 30-amino acid GHRH analog conjugated to a Drug Affinity Complex (DAC) -- a reactive lysine side chain that forms a covalent bond with serum albumin in vivo. This albumin-binding mechanism extends the circulating half-life to 6-8 days, enabling sustained GHRH receptor activation and weekly dosing protocols in growth hormone axis research. The prolonged exposure profile produces continuous, elevated GH and IGF-1 levels rather than pulsatile secretion.
Key Research Findings:
- Preclinical studies demonstrated sustained IGF-1 elevation for 6-14 days following a single subcutaneous injection
- Growth hormone levels remained elevated 2-3x above baseline for the full duration of the extended half-life window
- Albumin-binding studies confirmed >95% plasma protein association within 15 minutes of administration
- Weekly dosing protocols in rodent models produced consistent anabolic signaling without tachyphylaxis over 8-week studies
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.