5-AMINO-1MQ (NNMT Inhibitor)

5-AMINO-1MQ is a cell-permeable small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that is significantly overexpressed in white adipose tissue and has been linked to obesity and metabolic dysfunction. By selectively blocking NNMT activity, 5-AMINO-1MQ increases flux through the NAD+ salvage pathway, boosting intracellular NAD+ levels and enhancing cellular energy expenditure. The compound (MW 286.11 g/mol) is notable for its oral bioavailability in preclinical models, making it a versatile research tool for studying the intersection of epigenetic methylation, NAD+ metabolism, and adipose tissue biology.

Key Research Findings:

• Rodent studies demonstrated a 7% reduction in body weight over a 10-day treatment period without changes in food intake or locomotor activity
• Preclinical models showed significant upregulation of NAD+ salvage pathway activity and increased intracellular NAD+ concentrations in adipose tissue
• In vitro adipocyte studies demonstrated enhanced cellular energy expenditure and reduced lipid accumulation following NNMT inhibition
• Rodent studies showed decreased adipocyte size and reduced expression of lipogenic gene markers in treated versus control groups

For laboratory and research use only.