GLP-2 TRZ (GLP-1/GIP)
Dual Incretin Agonist • 39 Amino Acids
CAS: 2023788-19-2
GLP-2 TRZ is a 39-amino acid dual incretin agonist that simultaneously activates both GLP-1 and GIP receptors through a single lipopeptide molecule. Its C20 fatty diacid moiety with dual OEG linkers promotes albumin binding, conferring an extended pharmacokinetic profile suitable for once-weekly dosing research. Dual incretin agonism has shown superior glycemic and metabolic outcomes compared to mono-agonist approaches in preclinical studies, and GLP-2 TRZ is currently in Phase 3 clinical trials.
Key Research Findings:
- Diet-induced obesity (DIO) mouse models showed >20% body weight reduction over 4-week treatment protocols
- Glucose tolerance tests demonstrated ~50% improvement in AUC glucose compared to GLP-1-only analogs in rodent studies
- Dual receptor engagement produced 2-3x greater insulin secretion versus equimolar single-agonist controls in perfused islet assays
- Preclinical pharmacokinetics confirmed sustained plasma exposure over 120+ hours following a single subcutaneous dose
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.
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