Kisspeptin-10 (Metastin 45-54)

Kisspeptin-10 is a 10-amino acid truncated form of the kisspeptin neuropeptide that acts as a potent agonist at the KISS1R receptor (also known as GPR54). It serves as a master regulator of GnRH neuron activation in the hypothalamus, with picomolar binding affinity at its cognate receptor. Kisspeptin-10 has emerged as a critical research tool in reproductive neuroendocrinology, enabling precise investigation of the hypothalamic-pituitary-gonadal (HPG) axis and gonadotropin secretion dynamics. Studies in preclinical models have established it as one of the most potent known stimulators of LH and FSH release.

Key Research Findings:

• In vitro receptor binding assays demonstrated picomolar affinity at KISS1R/GPR54, confirming it as one of the highest-affinity endogenous receptor ligands characterized
• Rodent studies showed potent, dose-dependent stimulation of both LH and FSH secretion following peripheral and central administration
• Preclinical models established Kisspeptin-10 as a master upstream regulator of GnRH neuron firing and pulsatile gonadotropin release
• Neuroendocrine studies in animal models demonstrated direct activation of GnRH neurons in the arcuate nucleus and preoptic area

For laboratory and research use only.