CJC-1295 (Modified GRF 1-29, No DAC)
Growth Hormone Releasing Hormone • 29 Amino Acids
CAS: 863288-34-0
CJC-1295 (No DAC), also known as Modified GRF 1-29, is a 29-amino acid synthetic analog of growth hormone-releasing hormone (GHRH) with four amino acid substitutions that confer resistance to enzymatic degradation. Without the Drug Affinity Complex, it retains a short half-life of approximately 30 minutes, making it the preferred tool for studying pulsatile GH release patterns that mimic endogenous GHRH physiology. This pharmacokinetic profile preserves the natural GH pulsatility that longer-acting analogs tend to blunt.
Key Research Findings:
- Preclinical models demonstrated 2-10x increases in peak growth hormone secretion following single-dose administration
- GH pulsatility analysis confirmed preservation of endogenous pulse frequency and amplitude patterns, unlike DAC-conjugated analogs
- Receptor binding assays showed high-affinity GHRH-R engagement with an EC50 in the low nanomolar range (1-5 nM)
- Repeated dosing studies in rodents produced sustained IGF-1 elevation without desensitization over 14-day protocols
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.
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