MOTS-C (Mitochondrial-Derived Peptide)
Mitochondrial Peptide • 16 Amino Acids
CAS: 1627580-64-6
MOTS-C is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA gene of the mitochondrial genome -- one of the first mitochondrial-encoded signaling peptides identified. Its primary mechanism involves activation of the AMPK pathway, a master regulator of cellular energy homeostasis, leading to enhanced glucose uptake and fatty acid oxidation. MOTS-C represents a novel class of retrograde mitochondrial-nuclear signaling molecules with broad metabolic research applications.
Key Research Findings:
- Rodent studies demonstrated 30-40% improvement in exercise capacity (treadmill endurance) following MOTS-C administration
- Diet-induced obesity models showed significant resistance to weight gain and improved glucose tolerance with daily dosing protocols
- In vitro AMPK activation assays confirmed 2-3 fold increases in phospho-AMPK levels at micromolar concentrations
- Insulin sensitivity studies in aged mice showed restoration of glucose disposal rates to near-young-control levels following 14-day treatment
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.
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