Cagrilintide (Amylin Analog)
Long-Acting Amylin Analog
CAS: 1415456-99-3
Cagrilintide is a long-acting amylin analog engineered with a C18 fatty diacid modification that binds serum albumin, extending its pharmacological half-life to approximately 7 days in preclinical models. It acts as a potent agonist at both calcitonin and amylin receptors (AMY1/AMY3), key regulators of satiety signaling and gastric emptying. The extended duration of action enables weekly dosing protocols, making it a valuable tool for sustained metabolic pathway research.
Key Research Findings:
- Rodent studies demonstrated 30-40% reduction in cumulative food intake over 7-day dosing intervals
- Gastric emptying assays showed ~50% deceleration of gastric transit in preclinical models versus vehicle controls
- Combination studies with GLP-1 receptor agonists produced additive weight loss effects exceeding either agent alone by 15-20%
- Receptor binding assays confirmed high-affinity engagement at AMY1 and AMY3 receptors (Ki < 1 nM)
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.
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