GLP-3 RT (GLP-1/GIP/GCGR)
Triple Incretin Agonist • 39 Amino Acids
CAS: 2381089-83-2
GLP-3 RT is a 39-amino acid triple agonist peptide that simultaneously targets GLP-1, GIP, and glucagon (GCGR) receptors. Its C18 fatty diacid side-chain modification extends circulating half-life by promoting albumin binding, enabling sustained receptor engagement in preclinical models. Triple incretin agonism represents a mechanistic advance over single- and dual-receptor approaches, and GLP-3 RT is currently under evaluation in Phase 2 clinical trials.
Key Research Findings:
- Rodent studies demonstrated up to 24% body weight reduction in diet-induced obesity (DIO) models over 28 days
- Triple agonism produced ~40% greater metabolic improvement compared to GLP-1-only analogs in preclinical head-to-head comparisons
- In vitro receptor binding assays confirmed balanced nanomolar-range affinity across all three incretin receptors (EC50 < 10 nM)
- Pharmacokinetic profiling showed a ~5-fold extension in half-life versus unmodified peptide controls
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.
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