Vitamin B12 (Methylcobalamin) Liquid

This preparation supplies methylcobalamin — the bioactive, methyl-substituted form of cobalamin — as a pre-reconstituted 10 mg per 10 mL sterile liquid. Methylcobalamin is the obligate cofactor for methionine synthase (MTR / MS), the cytoplasmic enzyme that remethylates homocysteine to methionine using 5-methyl-tetrahydrofolate as the methyl donor. Intracellular conversion can also generate adenosylcobalamin (the mitochondrial cofactor for methylmalonyl-CoA mutase, MUT), making methylcobalamin a versatile substrate for studying cobalamin-dependent one-carbon and propionate metabolism. The liquid format eliminates the variability that in-house reconstitution introduces into dose-response work.

Key Research Findings:

• Acts as a direct cofactor for methionine synthase without requiring removal of a cyano group — a structural distinction from cyanocobalamin, which must be reductively decyanated before use
• Animal models of peripheral neuropathy report improvement in nerve conduction velocity under chronic methylcobalamin supplementation
• One-carbon-metabolism research uses methylcobalamin to probe the homocysteine–methionine–SAM axis without confounding intracellular conversion steps
• Liquid presentation enables consistent dosing in pharmacokinetic and PK/PD studies across labs
• Manufactured to research-grade specifications under controlled aseptic processing conditions

For laboratory and research use only.