MT-2 (Melanotan II)
Melanocortin Receptor Agonist • 7 Amino Acids
CAS: 121062-08-6
MT-2 (Melanotan II) is a 7-amino acid cyclic analog of alpha-melanocyte-stimulating hormone (alpha-MSH) featuring a lactam bridge that confers a rigid cyclic structure. It exhibits higher affinity for MC4R and MC3R subtypes compared to MT-1, and its cyclic conformation provides substantially enhanced metabolic stability with a half-life of approximately 2-3 hours versus minutes for native alpha-MSH. MT-2 has been extensively utilized in preclinical research to characterize melanocortin receptor signaling, structure-activity relationships, and downstream pathway activation.
Key Research Findings:
- In vitro receptor binding assays demonstrated superior MC4R/MC3R affinity compared to linear alpha-MSH analogs
- Pharmacokinetic studies in rodent models showed a circulating half-life of ~2-3 hours, representing a >30-fold improvement over native alpha-MSH
- Preclinical models confirmed broad melanocortin receptor activation with preferential MC4R engagement
- Structure-activity relationship studies established the lactam bridge as critical for both receptor selectivity and proteolytic resistance
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.