NAD+ (Nicotinamide Adenine Dinucleotide)
Coenzyme • Cellular Energy
CAS: 53-84-9
NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme present in every living cell, serving as an essential substrate for over 500 enzymatic reactions including those catalyzed by sirtuins (SIRT1-7) and poly(ADP-ribose) polymerases (PARPs). It functions as a central electron carrier in mitochondrial oxidative phosphorylation and a signaling molecule in DNA damage repair pathways. Rodent aging studies have documented an approximate 50% decline in tissue NAD+ levels by middle age, making NAD+ repletion a major focus of cellular senescence and longevity research.
Key Research Findings:
- NAD+ supplementation restored mitochondrial function and increased SIRT1 activity by 2-4 fold in aged mouse tissue models
- PARP-mediated DNA repair efficiency improved by ~60% when intracellular NAD+ pools were replenished in vitro
- Rodent studies demonstrated improved insulin sensitivity and 15-25% extension of healthspan markers with NAD+ precursor administration
- Cellular senescence assays showed 40-50% reduction in senescence-associated beta-galactosidase staining following NAD+ repletion
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.