GHK-Cu (Copper Peptide)
Copper Tripeptide Complex
CAS: 89030-95-5
GHK-Cu is a naturally occurring copper tripeptide complex (Gly-His-Lys-Cu²⁺) found in human plasma, saliva, and urine. Plasma concentrations decline significantly with age — from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60+. Genomic studies have identified GHK-Cu as a modulator of over 4,000 human genes involved in tissue remodeling, wound repair, and extracellular matrix organization. It promotes synthesis of collagen types I and III, decorin, and glycosaminoglycans while simultaneously upregulating antioxidant enzymes including superoxide dismutase (SOD).
Key Research Findings:
- Gene expression profiling demonstrated modulation of 4,000+ genes related to tissue remodeling, with significant upregulation of collagen I, collagen III, and decorin synthesis
- In vitro studies showed dose-dependent stimulation of glycosaminoglycan production and fibroblast proliferation in wound healing models
- Preclinical studies demonstrated anti-inflammatory effects via upregulation of SOD and other antioxidant enzyme pathways
- Age-related plasma concentration studies confirmed a ~60% decline from age 20 to 60+, correlating with reduced tissue repair capacity in aging models
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.