Semax (Neuropeptide)
Synthetic ACTH Analog • 7 Amino Acids
CAS: 80714-61-0
Semax is a 7-amino acid synthetic analog of the ACTH(4-10) fragment, extended with a Pro-Gly-Pro C-terminal sequence for enhanced enzymatic stability. The compound crosses the blood-brain barrier and has been shown to upregulate both brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression by 2-4x in rodent brain tissue. Notably, despite its structural origin from ACTH, Semax does not affect cortisol or adrenal steroidogenesis, making it a selective tool for neurotrophic signaling research. It has demonstrated neuroprotective properties in ischemia models, positioning it as a key compound in preclinical neuroscience investigations.
Key Research Findings:
- Rodent studies demonstrated 2-4x upregulation of BDNF and NGF mRNA expression in hippocampal and cortical tissue
- Preclinical ischemia models showed significant neuroprotective effects with reduced infarct volume when administered within therapeutic windows
- Pharmacological profiling confirmed no effect on cortisol, ACTH, or adrenal axis activation despite structural ACTH origin
- BBB penetration studies in animal models confirmed central nervous system bioavailability following peripheral administration
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.