ARA-290 (Innate Repair Receptor Agonist)
Erythropoietin-Derived Peptide • 11 Amino Acids
ARA-290 is a synthetic 11-amino acid peptide (MW 1115.2 g/mol) derived from the three-dimensional structure of erythropoietin (EPO), specifically engineered to selectively activate the innate repair receptor (IRR), a heterodimer of the EPO receptor and beta common receptor (EPOR/betacR). Unlike EPO itself, ARA-290 has no erythropoietic activity -- it does not stimulate red blood cell production, increase hematocrit, or promote thrombosis risk markers. This selective receptor targeting makes ARA-290 a valuable research tool for studying tissue-protective and neuroprotective signaling pathways independent of erythropoiesis.
Key Research Findings:
- In preclinical diabetic neuropathy models, ARA-290 demonstrated significant neuroprotective effects with restoration of small nerve fiber density in rodent corneal and epidermal tissue
- In vitro studies confirmed selective activation of the EPOR/betacR heterodimer without binding to the classical homodimeric EPO receptor responsible for erythropoiesis
- Rodent studies showed no measurable changes in hematocrit, reticulocyte count, or platelet activation markers at neuroprotective doses
- Preclinical models demonstrated anti-apoptotic signaling through JAK2/STAT5 and PI3K/Akt pathways in neuronal cell populations
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.