TB-500 (Thymosin Beta-4)
Thymosin Beta-4 Fragment • 43 Amino Acids
CAS: 885340-08-9
TB-500 is a 43-amino acid synthetic fragment of thymosin beta-4, an actin-sequestering protein present in virtually all nucleated cells. Its primary mechanism involves binding G-actin monomers and promoting actin polymerization, which drives cell migration, cytoskeletal reorganization, and new blood vessel formation. TB-500 has been widely studied in preclinical models of dermal wound healing, cardiac injury, and musculoskeletal repair.
Key Research Findings:
- Rodent dermal wound models demonstrated 40-50% faster wound closure compared to saline-treated controls over 7 days
- Cardiac injury studies in rats showed ~30% reduction in infarct size and improved ejection fraction following ischemia-reperfusion
- In vitro migration assays confirmed a 2-3x increase in endothelial cell migration at micromolar concentrations
- Inflammation markers (TNF-alpha, IL-6) were reduced by 40-60% in rodent joint and soft-tissue injury models
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.
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