AOD-9604 (Anti-Obesity Drug Fragment)
Modified HGH Fragment • 16 Amino Acids
CAS: 221231-10-3
AOD-9604 is a 16-amino acid modified fragment of human growth hormone (hGH) corresponding to the C-terminal region (amino acids 177-191) with a tyrosine residue added at position 177. This structural modification retains the lipolytic activity of full-length hGH while eliminating the growth-promoting, diabetogenic, and mitogenic effects associated with the intact hormone. AOD-9604 (MW 1815.08 g/mol) acts on adipose tissue by stimulating lipolysis and inhibiting lipogenesis through a mechanism distinct from the GH receptor, making it a valuable tool for studying fat metabolism independent of the somatotropic axis.
Key Research Findings:
- In preclinical models, AOD-9604 stimulated lipolysis in adipose tissue at rates comparable to the full hGH molecule without promoting longitudinal bone growth
- Rodent studies showed significant inhibition of lipogenesis in both visceral and subcutaneous fat depots
- Preclinical metabolic panels confirmed no measurable effect on circulating IGF-1, insulin, or blood glucose levels at effective lipolytic doses
- In vitro adipocyte assays demonstrated selective fat metabolism modulation without activation of the JAK2/STAT5 signaling cascade associated with hGH growth effects
For laboratory and research use only.
Add 1 more to save 5% per vial
Ships tomorrow
Today's 2:30 PM EST cutoff has passed
Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.