MT-1 (Melanotan I / Afamelanotide)
Melanocortin Receptor Agonist • 13 Amino Acids
CAS: 75921-69-6
MT-1, also known as Afamelanotide, is a 13-amino acid synthetic analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It functions as a non-selective melanocortin receptor agonist with binding activity across MC1R through MC5R, and has been characterized as approximately 10x more potent than native alpha-MSH in preclinical receptor activation assays. The compound stimulates eumelanin biosynthesis through MC1R-mediated signaling cascades, making it a widely used tool in melanocortin pathway research. Afamelanotide has received regulatory approval in the European Union within the context of erythropoietic protoporphyria research.
Key Research Findings:
- In vitro binding studies demonstrated ~10-fold greater potency than endogenous alpha-MSH at melanocortin receptors
- Preclinical models showed significant upregulation of eumelanin production via MC1R activation
- Rodent studies indicated sustained melanocortin receptor engagement due to enhanced metabolic stability compared to native alpha-MSH
- Photoprotection mechanism studies in animal models demonstrated reduced UV-induced DNA damage markers
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.