Epithalon (Epitalon)
Telomerase Activator • 4 Amino Acids
Epithalon (also known as Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (MW 390.35 g/mol), designed as a bioidentical analog of the naturally occurring epithalamin peptide isolated from the pineal gland. Its primary mechanism of action involves the activation of telomerase, the ribonucleoprotein enzyme responsible for maintaining telomere length during chromosomal replication. Epithalon has also been investigated for its modulatory effects on melatonin synthesis and circadian rhythm regulation, suggesting a broader role in neuroendocrine aging research.
Key Research Findings:
- In vitro studies demonstrated telomerase activation in human somatic cells, with measurable extension of telomere length in fetal fibroblast and retinal pigment epithelium cultures
- Rodent longevity studies showed a 31% increase in mean lifespan in treated cohorts compared to age-matched controls
- Preclinical models indicated restoration of evening melatonin peak amplitude in aged rodents, normalizing disrupted circadian rhythm markers
- In vitro research showed reactivation of telomerase catalytic subunit (TERT) gene expression in senescent cell populations
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.
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