AHK-Cu (Copper Tripeptide)
Copper Tripeptide Complex
CAS: 682809-81-0
AHK-Cu is a copper-binding tripeptide complex (Ala-His-Lys-Cu2+) with a molecular weight of 416.9 g/mol, studied primarily for its role in hair follicle biology and dermal tissue signaling. The peptide chelates a copper(II) ion through its histidine and lysine residues, forming a stable coordination complex that facilitates copper delivery to follicular tissue. AHK-Cu operates through a complementary but distinct mechanism from the related copper peptide GHK-Cu, with preferential biological activity observed in follicular microenvironments rather than broad dermal wound repair.
Key Research Findings:
- In vitro research demonstrated significant promotion of dermal papilla cell (DPC) proliferation at concentrations as low as 1 uM
- Preclinical studies showed upregulation of Wnt/beta-catenin pathway markers (beta-catenin, LEF-1, cyclin D1) in cultured hair follicle cells
- Rodent follicle organ culture models indicated prolongation of the anagen (growth) phase compared to untreated controls
- In vitro comparative studies suggested preferential activity in follicular tissue versus general dermal fibroblasts when compared to GHK-Cu
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.