Thymosin Alpha-1 (Tα1)
Immunomodulatory Peptide • 28 Amino Acids
Thymosin Alpha-1 (Ta1) is a 28-amino acid peptide originally isolated from thymosin fraction 5 of bovine thymic tissue. With a molecular weight of 3108.0 g/mol, Ta1 is one of the most extensively characterized immunomodulatory peptides, with approved research applications in over 35 countries for hepatitis B and C investigation contexts. Its mechanism of action involves enhancement of T-cell maturation and differentiation, activation of dendritic cells, augmentation of natural killer (NK) cell cytotoxicity, and stimulation of Toll-like receptors TLR2, TLR5, and TLR9. The peptide has a plasma half-life of approximately 2 hours.
Key Research Findings:
- In preclinical models, Ta1 increased CD4+ and CD8+ T-cell populations and restored T-cell function in immunosuppressed rodents
- In vitro studies demonstrated dose-dependent activation of dendritic cell maturation markers (CD80, CD86, MHC-II) and enhanced antigen presentation
- Rodent studies showed 2-3 fold enhancement of NK cell cytotoxic activity against target cell lines compared to untreated controls
- Preclinical research demonstrated synergistic immune activation when combined with TLR agonists, amplifying both innate and adaptive immune pathway signaling
For laboratory and research use only.
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Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.