KPV (Anti-Inflammatory Peptide)
Alpha-MSH Fragment • 3 Amino Acids
KPV is a naturally occurring tripeptide (Lys-Pro-Val, MW 342.43 g/mol) derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite being only three amino acids in length, KPV retains the potent anti-inflammatory signaling activity of the parent hormone while lacking melanotropic effects (no melanocortin receptor activation or pigmentation changes). Its primary mechanism involves direct inhibition of NF-kB nuclear translocation, the master transcription factor regulating pro-inflammatory cytokine expression. KPV has demonstrated particular research interest in mucosal immunology and gastrointestinal inflammation models.
Key Research Findings:
- In vitro studies demonstrated dose-dependent inhibition of NF-kB nuclear translocation and downstream suppression of IL-1beta, TNF-alpha, and IL-6 production in activated macrophages
- Rodent colitis models showed 50-70% reduction in key inflammatory markers (MPO activity, cytokine levels) compared to untreated controls
- Preclinical studies demonstrated enhanced intestinal epithelial barrier integrity and accelerated mucosal healing in chemically induced colitis models
- In vitro research confirmed that KPV exerts anti-inflammatory effects independent of melanocortin MC1R/MC3R/MC4R receptor binding
For laboratory and research use only.
Add 1 more to save 5% per vial
Ships tomorrow
Today's 2:30 PM EST cutoff has passed
Technical Details & Purity Analysis
Documented Studies & Applications
This peptide is intended for laboratory research purposes only. Below are documented research applications.
Storage & Reconstitution
Storage Conditions
Store lyophilized peptide at -20°C for long-term storage (up to 24 months). For short-term storage (up to 4 weeks), 4°C is acceptable. Keep away from light and moisture.
Reconstitution
Reconstitute with bacteriostatic water or sterile water. Add solvent slowly down the side of the vial. Do not shake vigorously. Store reconstituted peptide at 4°C.
Handling Precautions
Handle with appropriate laboratory safety equipment. This product is for research use only and not for human consumption.